miRGen 2.0: a database of microRNA genomic information and regulation.

TitlemiRGen 2.0: a database of microRNA genomic information and regulation.
Publication TypeJournal Article
Year of Publication2010
AuthorsAlexiou, P, Vergoulis, T, Gleditzsch, M, Prekas, G, Dalamagas, T, Megraw, M, Grosse, I, Sellis, T, Hatzigeorgiou, AG
JournalNucleic Acids Res
IssueDatabase issue
Date Published2010 Jan
Keywords3' Untranslated Regions, Algorithms, Animals, Cell Line, Tumor, Computational Biology, Databases, Genetic, Databases, Nucleic Acid, Humans, Information Storage and Retrieval, Internet, Mice, MicroRNAs, Polymorphism, Single Nucleotide, Software, Transcription Factors

MicroRNAs are small, non-protein coding RNA molecules known to regulate the expression of genes by binding to the 3'UTR region of mRNAs. MicroRNAs are produced from longer transcripts which can code for more than one mature miRNAs. miRGen 2.0 is a database that aims to provide comprehensive information about the position of human and mouse microRNA coding transcripts and their regulation by transcription factors, including a unique compilation of both predicted and experimentally supported data. Expression profiles of microRNAs in several tissues and cell lines, single nucleotide polymorphism locations, microRNA target prediction on protein coding genes and mapping of miRNA targets of co-regulated miRNAs on biological pathways are also integrated into the database and user interface. The miRGen database will be continuously maintained and freely available at http://www.microrna.gr/mirgen/.

Alternate JournalNucleic Acids Res.
PubMed ID19850714
PubMed Central IDPMC2808909