02199nas a2200301   4500008004100000022001400041245009100055210006900146260001300215300001200228490000700240520133700247653001201584653003701596653002801633653001301661653001101674653001301685653000901698653001401707653000901721653002801730100001801758700002401776700001801800700003001818856004901848       2007                        eng d  a1362-496200amiRGen: a database for the study of animal microRNA genomic organization and function.0 amiRGen a database for the study of animal microRNA genomic organ  c2007 Jan  aD149-550 v353 a<p>miRGen is an integrated database of (i) positional relationships between animal miRNAs and genomic annotation sets and (ii) animal miRNA targets according to combinations of widely used target prediction programs. A major goal of the database is the study of the relationship between miRNA genomic organization and miRNA function. This is made possible by three integrated and user friendly interfaces. The Genomics interface allows the user to explore where whole-genome collections of miRNAs are located with respect to UCSC genome browser annotation sets such as Known Genes, Refseq Genes, Genscan predicted genes, CpG islands and pseudogenes. These miRNAs are connected through the Targets interface to their experimentally supported target genes from TarBase, as well as computationally predicted target genes from optimized intersections and unions of several widely used mammalian target prediction programs. Finally, the Clusters interface provides predicted miRNA clusters at any given inter-miRNA distance and provides specific functional information on the targets of miRNAs within each cluster. All of these unique features of miRGen are designed to facilitate investigations into miRNA genomic organization, co-transcription and targeting. miRGen can be freely accessed at http://www.diana.pcbi.upenn.edu/miRGen.</p>10aAnimals10aData Interpretation, Statistical10aDatabases, Nucleic Acid10aGenomics10aHumans10aInternet10aMice10aMicroRNAs10aRats10aUser-Computer Interface1 aMegraw, Molly1 aSethupathy, Praveen1 aCorda, Benoit1 aHatzigeorgiou, Artemis, G  uhttps://megraw.cgrb.oregonstate.edu/node/329