@article {320,
	title = {Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits.},
	journal = {Genome Biol},
	volume = {14},
	year = {2013},
	month = {2013},
	pages = {R85},
	abstract = {<p>WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes.</p>},
	keywords = {Algorithms, Animals, Arabidopsis, Computational Biology, Drosophila melanogaster, Gene Expression Regulation, Gene Regulatory Networks, Humans, MicroRNAs, Molecular Sequence Annotation, Nucleic Acid Conformation, Software, Transcription Factors},
	issn = {1474-760X},
	doi = {10.1186/gb-2013-14-8-r85},
	author = {Megraw, Molly and Mukherjee, Sayan and Ohler, Uwe}
}
