@article {323,
	title = {Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency.},
	journal = {J Biol Chem},
	volume = {285},
	year = {2010},
	month = {2010 Oct 22},
	pages = {33358-70},
	abstract = {<p>Certain primary transcripts of miRNA (pri-microRNAs) undergo RNA editing that converts adenosine to inosine. The Epstein-Barr virus (EBV) genome encodes multiple microRNA genes of its own. Here we report that primary transcripts of ebv-miR-BART6 (pri-miR-BART6) are edited in latently EBV-infected cells. Editing of wild-type pri-miR-BART6 RNAs dramatically reduced loading of miR-BART6-5p RNAs onto the microRNA-induced silencing complex. Editing of a mutation-containing pri-miR-BART6 found in Daudi Burkitt lymphoma and nasopharyngeal carcinoma C666-1 cell lines suppressed processing of miR-BART6 RNAs. Most importantly, miR-BART6-5p RNAs silence Dicer through multiple target sites located in the 3\&$\#$39;-UTR of Dicer mRNA. The significance of miR-BART6 was further investigated in cells in various stages of latency. We found that miR-BART6-5p RNAs suppress the EBNA2 viral oncogene required for transition from immunologically less responsive type I and type II latency to the more immunoreactive type III latency as well as Zta and Rta viral proteins essential for lytic replication, revealing the regulatory function of miR-BART6 in EBV infection and latency. Mutation and A-to-I editing appear to be adaptive mechanisms that antagonize miR-BART6 activities.</p>},
	keywords = {Cell Line, Tumor, Epstein-Barr Virus Infections, Epstein-Barr Virus Nuclear Antigens, Gene Silencing, Herpesvirus 4, Human, Humans, Immediate-Early Proteins, MicroRNAs, Ribonuclease III, RNA Editing, RNA, Viral, Trans-Activators, Viral Proteins, Virus Latency},
	issn = {1083-351X},
	doi = {10.1074/jbc.M110.138362},
	author = {Iizasa, Hisashi and Wulff, Bjorn-Erik and Alla, Nageswara R and Maragkakis, Manolis and Megraw, Molly and Hatzigeorgiou, Artemis and Iwakiri, Dai and Takada, Kenzo and Wiedmer, Andreas and Showe, Louise and Lieberman, Paul and Nishikura, Kazuko}
}
@article {324,
	title = {miRGen 2.0: a database of microRNA genomic information and regulation.},
	journal = {Nucleic Acids Res},
	volume = {38},
	year = {2010},
	month = {2010 Jan},
	pages = {D137-41},
	abstract = {<p>MicroRNAs are small, non-protein coding RNA molecules known to regulate the expression of genes by binding to the 3\&$\#$39;UTR region of mRNAs. MicroRNAs are produced from longer transcripts which can code for more than one mature miRNAs. miRGen 2.0 is a database that aims to provide comprehensive information about the position of human and mouse microRNA coding transcripts and their regulation by transcription factors, including a unique compilation of both predicted and experimentally supported data. Expression profiles of microRNAs in several tissues and cell lines, single nucleotide polymorphism locations, microRNA target prediction on protein coding genes and mapping of miRNA targets of co-regulated miRNAs on biological pathways are also integrated into the database and user interface. The miRGen database will be continuously maintained and freely available at http://www.microrna.gr/mirgen/.</p>},
	keywords = {3{\textquoteright} Untranslated Regions, Algorithms, Animals, Cell Line, Tumor, Computational Biology, Databases, Genetic, Databases, Nucleic Acid, Humans, Information Storage and Retrieval, Internet, Mice, MicroRNAs, Polymorphism, Single Nucleotide, Software, Transcription Factors},
	issn = {1362-4962},
	doi = {10.1093/nar/gkp888},
	author = {Alexiou, Panagiotis and Vergoulis, Thanasis and Gleditzsch, Martin and Prekas, George and Dalamagas, Theodore and Megraw, Molly and Grosse, Ivo and Sellis, Timos and Hatzigeorgiou, Artemis G}
}
