|Title||MicroRNA promoter element discovery in Arabidopsis.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Megraw, M, Baev, V, Rusinov, V, Jensen, ST, Kalantidis, K, Hatzigeorgiou, AG|
|Date Published||2006 Sep|
|Keywords||Arabidopsis, Base Sequence, Binding Sites, Databases, Genetic, Feedback, Physiological, Genes, Plant, MicroRNAs, Promoter Regions, Genetic, TATA Box, Transcription Factors, Transcription Initiation Site|
In this study we present a method of identifying Arabidopsis miRNA promoter elements using known transcription factor binding motifs. We provide a comparative analysis of the representation of these elements in miRNA promoters, protein-coding gene promoters, and random genomic sequences. We report five transcription factor (TF) binding motifs that show evidence of overrepresentation in miRNA promoter regions relative to the promoter regions of protein-coding genes. This investigation is based on the analysis of 800-nucleotide regions upstream of 63 experimentally verified Transcription Start Sites (TSS) for miRNA primary transcripts in Arabidopsis. While the TATA-box binding motif was also previously reported by Xie and colleagues, the transcription factors AtMYC2, ARF, SORLREP3, and LFY are identified for the first time as overrepresented binding motifs in miRNA promoters.
|PubMed Central ID||PMC1557699|
MicroRNA promoter element discovery in Arabidopsis.
Submitted by Megraw Lab Admin on Tue, 2016-07-12 22:18